JARB Journal of Animal Reproduction and Biotehnology

OPEN ACCESS pISSN: 2671-4639
eISSN: 2671-4663

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Reproductive & Developmental Biology 2003; 27(1): 1-7

Published online March 30, 2003

Copyright © The Korean Society of Animal Reproduction and Biotechnology.

성장관련 유전자를 이용한 형질전환토끼의 생산에 관한 연구

김현주,강회성,최화식,임경순,진동일

선문대학교 응용생물과학부,김천대학교 임상병리학과,서울대학교 동물자원과학과

Abstract

Transgenic rabbits were produced by DNA microinjection using growth hormone receptor (GHR) and IGF-1 receptor (IGF-1R) genes fused to metallothionein(MT) promoter. The overall efficiencies for production of transgenic rabbits were 3.2% and 3.1% for GHR and IGF-lR genes, respectively. Founder rabbits transmitted transgenes to their progenies through medelian fashion. Growth rate of GHR and IGF-lR transgenic rabbits was significantly faster than that of non-transgenic rabbits. Transgenic rabbits grew large. (25% and 15% increase in body weight of GHR and IGF-lR transgenic rabbits, respectively) than non-transgenic rabbits and organ weight of transgenic rabbits increased, suggesting that GHR and IGF-1R genes affects growth rates in transgenic rabbits.

Keywords: Transgenic rabbits, Growth hormone receptor gene, ICF-1 receptor gene, Growth rate

Article

Reproductive & Developmental Biology 2003; 27(1): 1-7

Published online March 30, 2003

Copyright © The Korean Society of Animal Reproduction and Biotechnology.

성장관련 유전자를 이용한 형질전환토끼의 생산에 관한 연구

김현주,강회성,최화식,임경순,진동일

선문대학교 응용생물과학부,김천대학교 임상병리학과,서울대학교 동물자원과학과

Abstract

Transgenic rabbits were produced by DNA microinjection using growth hormone receptor (GHR) and IGF-1 receptor (IGF-1R) genes fused to metallothionein(MT) promoter. The overall efficiencies for production of transgenic rabbits were 3.2% and 3.1% for GHR and IGF-lR genes, respectively. Founder rabbits transmitted transgenes to their progenies through medelian fashion. Growth rate of GHR and IGF-lR transgenic rabbits was significantly faster than that of non-transgenic rabbits. Transgenic rabbits grew large. (25% and 15% increase in body weight of GHR and IGF-lR transgenic rabbits, respectively) than non-transgenic rabbits and organ weight of transgenic rabbits increased, suggesting that GHR and IGF-1R genes affects growth rates in transgenic rabbits.

Keywords: Transgenic rabbits, Growth hormone receptor gene, ICF-1 receptor gene, Growth rate

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