JARB Journal of Animal Reproduction and Biotehnology

OPEN ACCESS pISSN: 2671-4639
eISSN: 2671-4663

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Reproductive & developmental biology 2010; 34(4): 305-308

Published online December 31, 2010

Copyright © The Korean Society of Animal Reproduction and Biotechnology.

Antidiabetic Activities Analysis by Oral Glucose Tolerance Test in Rats

Myung-Hwa Kang,Mi-Kyeong Choi

Dept. of Food Science and Nutrition, Hoseo University,Dept. of Food and Nutrition, Kongju National University

Abstract

In this study, we conducted an oral glucose tolerance test (OGTT) so as to compare antidiabetic activities of general potatoes, purple-flesh potatoes, and potato pigments in rats at various concentration levels. After allowing the rats to abstain from food for 12 hours, 10%/20% general potato, purple-flesh potato, and potato extract was orally administered to rats at 100 and 500 mg/kg concentrations. The blood glucose level was measured after an hour. Then, immediately, 1.5 g/kg of sucrose was administered through the abdominal cavity and the blood glucose measured after 30, 60, 120, and 180 minutes. 20% purple-flesh potato group and 10% general potato group, both 100 and 500 mg/kg, showed a significant concentration-dependent decrease in blood glucose levels after 30 minutes. The 100 mg/kg potato pigment group also showed a statistically significant decrease after 30 minutes. In conclusion, administration of 10% general potato, 20% purple-flesh potato, and potato pigment can reduce blood glucose level in an OGTT using rats.

Keywords: OGTT, Potato, Antidiabetic Activities, Rats