Vasculature malformation displayed by representative larvae at the 72 hpf development stage. (A) Angiogenic process easily visualized in eGFP-expressed fli1 transgenic zebrafish larvae throughout embryogenesis. As morphological variables predominated in response to isoprocarb exposure, newly formed ISV sprouts (white arrows) were undeveloped and DLAV (orange arrow) was expressed with unclear boundaries as compared with those in normal larvae in solvent controls. Scale bar: 100 μm for 5× magnification and 50 μm for 10× magnification. (B, C) Determination of the damage in ISVs connected with the cardiovascular system indicated that the length (B) and disruption (C) in ISV formation were affected in a concentration-dependent manner at 72 h of isoprocarb treatment (*p < 0.05, **p < 0.01, and ***p < 0.001).