White blood cell count (WBC) (cells/uL) in mice 4 weeks after administration of Lonicera caerulea (250 mg/kg, 0.5 mL/day). HS (Heat shock group), HB (Honey berry group), HB + HS (Honey berry + Heat shock group). (A) Neutrophil and Lymphocyte WBC. HS groups significantly increased the number of neutrophils compared to the control group. The number of neutrophils increased due to damage to the testicular tissue by thermal shock. In the case of the HB group, there was no significant difference when compared with the control group, and there was a significant decrease when compared with the HS group. On the other hand, the HB + HS group damaged testis and leukocyte DNA by heat shock, but the number of neutrophils increased due to the antioxidant effect of a large amount of polyphenol contained in HB. Lymphocyte results showed no significant difference. (B) Monocyte, Eosinophil, and Basophil WBC, in the HB + HS group, the number of leukocytes appears to be increased due to the recovery response from heat shock. but there was no significant difference in the results for Monocyte, Eosinophil, and Basophil. Value is mean ± SD of 4 mice group (SPSS, Tukey HSD, n = 20), *p < 0.05 vs. the control group, ★p < 0.05 vs. the HB group.