Table 6

Gene ontology terms of genes associated with the identified CNVRs

Term	Count	Percentage (%) of genes	p-value
Molecular function
GO:0016787~hydrolase activity	50	18.45	0.002
GO:0004722~protein serine/threonine phosphatase activity	5	1.85	0.005
GO:0016788~hydrolase activity, acting on ester bonds	19	7.01	0.009
GO:0005216~ion channel activity	13	4.80	0.013
GO:0022838~substrate-specific channel activity	13	4.80	0.017
GO:0022839~ion gated channel activity	4	1.48	0.024
GO:0005261~cation channel activity	10	3.69	0.025
GO:0015267~channel activity	13	4.80	0.025
GO:0022803~passive transmembrane transporter activity	13	4.80	0.025
GO:0016646~oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	3	1.11	0.028
GO:0015269~calcium-activated potassium channel activity	3	1.11	0.031
GO:0022836~gated channel activity	10	3.69	0.032
GO:0098811~transcriptional repressor activity, RNA polymerase II activating transcription factor binding	4	1.48	0.032
GO:0001190~transcriptional activator activity, RNA polymerase II transcription factor binding	4	1.48	0.032
GO:0036094~small molecule binding	45	16.61	0.032
GO:0052689~carboxylic ester hydrolase activity	6	2.21	0.033
GO:0000166~nucleotide binding	42	15.50	0.040
GO:1901265~nucleoside phosphate binding	42	15.50	0.040
GO:0046965~retinoid X receptor binding	2	0.74	0.046
GO:0042578~phosphoric ester hydrolase activity	10	3.69	0.050
Cellular component
GO:0005737~cytoplasm	141	52.03	0.005
GO:0005773~vacuole	22	8.12	0.008
GO:0005769~early endosome	8	2.95	0.018
GO:0005774~vacuolar membrane	12	4.43	0.022
GO:0005622~intracellular	183	67.53	0.023
GO:0005768~endosome	15	5.54	0.024
GO:0044424~intracellular part	176	64.94	0.026
GO:0044437~vacuolar part	12	4.43	0.029
GO:0098588~bounding membrane of organelle	23	8.49	0.043
GO:0015630~microtubule cytoskeleton	21	7.75	0.048
GO:0005815~microtubule organizing center	14	5.17	0.049
Biological process
GO:0007033~vacuole organization	8	2.95	0.010
GO:1901700~response to oxygen-containing compound	21	7.75	0.014
GO:0010508~positive regulation of autophagy	5	1.85	0.017
GO:0010738~regulation of protein kinase A signaling	3	1.11	0.023
GO:0050728~negative regulation of inflammatory response	5	1.85	0.030
GO:0055086~nucleobase-containing small molecule metabolic process	14	5.17	0.035
GO:0044281~small molecule metabolic process	29	10.70	0.037
GO:0010506~regulation of autophagy	7	2.58	0.042
GO:0006182~cGMP biosynthetic process	3	1.11	0.042
GO:0009152~purine ribonucleotide biosynthetic process	7	2.58	0.044
GO:0043149~stress fiber assembly	4	1.48	0.046
GO:0030038~contractile actin filament bundle assembly	4	1.48	0.046
GO:0006164~purine nucleotide biosynthetic process	7	2.58	0.048
GO:0009165~nucleotide biosynthetic process	8	2.95	0.049
GO:0009409~response to cold	3	1.11	0.049

Journal of Animal Reproduction and Biotechnology 2023;38:158-66 https://doi.org/10.12750/JARB.38.3.158