Effects of administration of cisplatin and cisplatin + LPS to generate renal injury mouse model. (A) Experimental schedule of cisplatin and LPS administration. Schematic representation of the treatment groups and dosing schedule. (B) Physiological and biochemical effects of cisplatin and cisplatin + LPS treatment. The co-administration of cisplatin and LPS was associated with significant reductions in body weight and renal weight, area, and BUN (5-8 mice per group) suggesting enhanced renal injury compared to the control group. Mean ± SEM, 5-8 mice per group. *p < 0.05 by ANOVA with Tukey’s analysis and t-test. Cis, cisplatin; LPs, lipopolysaccharide; Cis + LPS, cisplatin + lipopolysaccharide; BUN, blood urea nitrogen.
pISSN: 2671-4639
