JARB Journal of Animal Reproduction and Biotehnology

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Journal of Embryo Transfer 2011; 26(4): 257-263

Published online December 31, 2011

Copyright © The Korean Society of Animal Reproduction and Biotechnology.

Protective Effects of Silymarin against the Toxicity of Bisphenol A (BPA) on Boar Sperm Quality

Jang, Hyun-Young, Kong, Hong-Sik, Choi, Byoung-Yang, Shin, Jong-Suh, Cheong, Hee-Tae, Kim, Jong-Tack, Park, In-Chul, Park, Choon-Keun, Yang, Boo-Keun

College of Animal Life Science, Kangwon National University, Chuncheon 201-701, Korea,School of Veterinary Medicine, Kangwon National University, Chuncheon 201-701, Korea,Dept. of Biotechnology, Genomic Engineering Center, Hankyong National University, Ansung 456-749, Korea

Abstract

BPA, a diphenyl compound containing groups, that make it structurally similar to synthetic estrogen and is considered as one of the major endocrine disruptors. Silymarin has extensively been used to prevent and/or alleviate some human disease, especially for the treatment of adverse liver conditions. It has an antioxidative efficacy and cancer preventive efficacy. Therefore, we examined the hypothesis that silymarin can inhibit BPA-induced toxicity in boar sperm duing in vitro storage. Sperm characteristics (motility, viability, membrane integrity and mitochondrion activity) in semen exposed to BPA (10~200 uM) were sharply lowered, while it increase in a dose and time dependent manner due to silymarin addition (50~200 uM) into semen extender in the presence of BPA (100 uM). All of the evaluated characteristics were gradually improved in the groups that were treated with silymarin (50~200 uM) in the presence of BPA (100 uM) in comparison to BPA 100 uM alone group, irrespective of incubation periods (3 and 6 h). These results demonstrate that silymarin can ameliorate the toxicity of BPA on boar sperm characteristics during in vitro storage, suggesting that silymarin indirectly act as an antioxidant.

Keywords: endocrine disruptors, silymarin, bisphenol A, sperm characteristic, mitochodria activity

Article

Journal of Embryo Transfer 2011; 26(4): 257-263

Published online December 31, 2011

Copyright © The Korean Society of Animal Reproduction and Biotechnology.

Protective Effects of Silymarin against the Toxicity of Bisphenol A (BPA) on Boar Sperm Quality

Jang, Hyun-Young, Kong, Hong-Sik, Choi, Byoung-Yang, Shin, Jong-Suh, Cheong, Hee-Tae, Kim, Jong-Tack, Park, In-Chul, Park, Choon-Keun, Yang, Boo-Keun

College of Animal Life Science, Kangwon National University, Chuncheon 201-701, Korea,School of Veterinary Medicine, Kangwon National University, Chuncheon 201-701, Korea,Dept. of Biotechnology, Genomic Engineering Center, Hankyong National University, Ansung 456-749, Korea

Abstract

BPA, a diphenyl compound containing groups, that make it structurally similar to synthetic estrogen and is considered as one of the major endocrine disruptors. Silymarin has extensively been used to prevent and/or alleviate some human disease, especially for the treatment of adverse liver conditions. It has an antioxidative efficacy and cancer preventive efficacy. Therefore, we examined the hypothesis that silymarin can inhibit BPA-induced toxicity in boar sperm duing in vitro storage. Sperm characteristics (motility, viability, membrane integrity and mitochondrion activity) in semen exposed to BPA (10~200 uM) were sharply lowered, while it increase in a dose and time dependent manner due to silymarin addition (50~200 uM) into semen extender in the presence of BPA (100 uM). All of the evaluated characteristics were gradually improved in the groups that were treated with silymarin (50~200 uM) in the presence of BPA (100 uM) in comparison to BPA 100 uM alone group, irrespective of incubation periods (3 and 6 h). These results demonstrate that silymarin can ameliorate the toxicity of BPA on boar sperm characteristics during in vitro storage, suggesting that silymarin indirectly act as an antioxidant.

Keywords: endocrine disruptors, silymarin, bisphenol A, sperm characteristic, mitochodria activity

JARB Journal of Animal Reproduction and Biotehnology

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OPEN ACCESS pISSN: 2671-4639
eISSN: 2671-4663